Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
Medchemexpress LLC Bio-AMS TFA | 00-00-0 | 98.0% | 685.65 g/mol | C22H30F3N9O9S2 | 5 MG
Bio-AMS TFA is a bacterial biotin protein ligase inhibitor supplied as the trifluoroacetate (TFA) salt for research use. It shows selective activity against Mycobacterium tuberculosis and disrupts fatty acid and lipid biosynthesis.
- Potent biotin protein ligase inhibition.
- Selective activity against Mycobacterium tuberculosis.
- Provided as the TFA salt to aid handling and solubility.
- High purity: 98.0%.
- Molecular weight 685.65 g/mol; formula C22H30F3N9O9S2.
- Available in small research pack sizes, including 5 mg.
- Suitable for biochemical and microbiology research applications.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
TARGETMOL CHEMICALS INC 6H05 TFA 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. 6H05 TFA (6H05 trifluoroacetate) is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor. purity: 98%
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | 99.9% | 545.46 g·mol⁻¹ | C23H24F5N5O5 | 10 MG
NH2-UAMC1110 TFA is the trifluoroacetic acid salt of an amino-functionalized derivative of UAMC1110. It is used as a chemical intermediate for the synthesis of FAPI-QS and other FAP-targeting imaging agents and radiotracers. The compound is supplied with high purity and is intended for research and radiochemistry applications where an amino handle is required for conjugation and labeling.
- High purity (99.89%) suitable for synthetic and radiochemistry use.
- Amino-functionalized derivative for conjugation and labeling.
- Trifluoroacetic acid salt form for improved handling and solubility.
- Intended for use as an intermediate in FAP-targeting radiotracer synthesis.
- Characterized by CAS number 2990021-73-1 and formula C23H24F5N5O5.
Selleck Chemical LLC Iberiotoxin TFA-E0015-5MG
Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus Iberiotoxin is a potent blocker of the large conductance Ca(2 )-activated K channel with a Kd of 1 nM
Selleck Chemical LLC Iberiotoxin TFA-E0015-25MG
Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus Iberiotoxin is a potent blocker of the large conductance Ca(2 )-activated K channel with a Kd of 1 nM